Health Economics
Dr. Daniel Mark’s most widely recognized contribution has been to develop the field of empirically based economic analysis and patient reported outcomes in large cardiovascular disease randomized trials. In the area of economic analysis, a pivotal early publication was the cost-effectiveness analysis of the GUSTO-I trial. This highly controversial trial pitted a genetically engineered molecule against an older “low tech” therapy for acute myocardial infarction. Dr. Mark obtained independent funding to collect detailed prospective economic and quality of life information on 3000 North American patients in this trial. The resulting work led to two first-author papers in the New England Journal of Medicine. In viewing this accomplishment, it is important to recognize that the work was done during a period when the major medical journals had grown quite cynical about cost-effectiveness analyses because of their perceived domination by industry concerns. Indeed, the New England Journal of Medicine had just published an editorial saying that they would no longer publish such analyses; but upon receiving Dr. Mark’s paper they decided not only to publish it but also to solicit an editorial about it. This editorial stated that this study “sets a new standard for the integration of cost effectiveness into randomized trials.” Dr. Mark has gone on to conduct prospective economic analyses as part of the leadership team of over a dozen guideline-changing cardiovascular clinical trials.
Health Economics Studies
Health Economics Research Publications
Cost-Effectiveness of Left Atrial Appendage Occlusion: A Case Based on Facts Not in Evidence?
Pokorney SD, Mark DB.
Circ Arrhythm Electrophysiol. 2016 Jun;9(6). pii: e004223. doi: 10.1161/CIRCEP.116.004223. No abstract available. PMID: 27307520
Economic Outcomes With Anatomical Versus Functional Diagnostic Testing for Coronary Artery Disease.
Mark DB, Federspiel JJ, Cowper PA, Anstrom KJ, Hoffmann U, Patel MR, Davidson-Ray L, Daniels MR, Cooper LS, Knight JD, Lee KL, Douglas PS; PROMISE Investigators..
Ann Intern Med. 2016 Jul 19;165(2):94-102. doi: 10.7326/M15-2639. PMID: 27214597
Economic analysis of ticagrelor therapy from a U.S. perspective: results from the PLATO study.
Cowper PA, Pan W, Anstrom KJ, Kaul P, Wallentin L, Davidson-Ray L, Nikolic E, Janzon M, Levin LÅ, Cannon CP, Harrington RA, Mark DB.
J Am Coll Cardiol. 2015 Feb 10;65(5):465-76. doi: 10.1016/j.jacc.2014.11.034. PMID: 25660925 Free Article
The economics of heart failure.
Kazi DS, Mark DB.
Heart Fail Clin. 2013 Jan;9(1):93-106. doi: 10.1016/j.hfc.2012.09.005. Review. No abstract available. PMID: 23168320
Mark DB, Mentz RJ.
Circulation. 2012 Jun 26;125(25):3243-5. doi: 10.1161/CIRCULATIONAHA.112.093120. Review. No abstract available.
PMID: 22733341 Free Article
Eisenstein EL, Sun JL, Anstrom KJ, DeLong ER, Szczech LA, Mark DB.
J Med Syst. 2009 Aug;33(4):287-97. PMID: 19697695 Free PMC Article
Mark DB, Knight JD, Velazquez EJ, Howlett JG, Spertus JA, Djokovic LT, Harding TM, Rankin GR, Drew LA, Szygula-Jurkiewicz B, Adlbrecht C, Anstrom KJ; Surgical Treatment for Ischemic Heart Failure (STICH) Trial Investigators..
Am Heart J. 2009 May;157(5):837-44, 844.e1-3. doi: 10.1016/j.ahj.2009.03.008. PMID: 19376309 Free PMC Article
Mark DB, Knight JD, Cowper PA, Davidson-Ray L, Anstrom KJ.
Am Heart J. 2008 Oct;156(4):698-705. doi: 10.1016/j.ahj.2008.05.032. PMID: 18926150
Nelson CL, Sun JL, Tsiatis AA, Mark DB.
Stat Med. 2008 Nov 20;27(26):5525-55. doi: 10.1002/sim.3355. PMID: 18613251
Liao L, Anstrom KJ, Gottdiener JS, Pappas PA, Whellan DJ, Kitzman DW, Aurigemma GP, Mark DB, Schulman KA, Jollis JG.
Am Heart J. 2007 Feb;153(2):245-52. PMID: 17239685
The high cost of implantable defibrillators.
Hlatky MA, Mark DB.
Eur Heart J. 2007 Feb;28(4):388-91. Review. PMID: 17032689 Free Article
Mark DB, Nelson CL, Anstrom KJ, Al-Khatib SM, Tsiatis AA, Cowper PA, Clapp-Channing NE, Davidson-Ray L, Poole JE, Johnson G, Anderson J, Lee KL, Bardy GH; SCD-HeFT Investigators..
Circulation. 2006 Jul 11;114(2):135-42. PMID: 16818817 Free Article
Eisenstein EL, Yusuf S, Bindal V, Bourassa MG, Horney A, Collins JF, Mark DB; DIG investigators..
J Card Fail. 2006 Jun;12(5):336-42. PMID: 16762794
Costs for heart failure with normal vs reduced ejection fraction.
Liao L, Jollis JG, Anstrom KJ, Whellan DJ, Kitzman DW, Aurigemma GP, Mark DB, Schulman KA, Gottdiener JS.
Arch Intern Med. 2006 Jan 9;166(1):112-8. PMID: 16401819
Kaul P, Armstrong PW, Cowper PA, Eisenstein EL, Granger CB, Van de Werf F, Mark DB.
Am Heart J. 2005 Apr;149(4):637-44. PMID: 15990746
Surgeons’ economic profiles: can we get the “right” answers?
Eisenstein EL, Bethea CF, Muhlbaier LH, Davidian M, Peterson ED, Stafford JA, Mark DB.
J Med Syst. 2005 Apr;29(2):111-24. PMID: 15931798
Reed SD, Anstrom KJ, Bakhai A, Briggs AH, Califf RM, Cohen DJ, Drummond MF, Glick HA, Gnanasakthy A, Hlatky MA, O’Brien BJ, Torti FM Jr, Tsiatis AA, Willan AR, Mark DB, Schulman KA.
Am Heart J. 2005 Mar;149(3):434-43. PMID: 15864231
Clinical and economic implications of the Multicenter Automatic Defibrillator Implantation Trial-II.
Al-Khatib SM, Anstrom KJ, Eisenstein EL, Peterson ED, Jollis JG, Mark DB, Li Y, O’Connor CM, Shaw LK, Califf RM.
Ann Intern Med. 2005 Apr 19;142(8):593-600. PMID: 15838065
Economic impact of new interventional therapies: are we asking the right questions?
Kong DF, Mark DB.
J Am Coll Cardiol. 2004 Nov 2;44(9):1809-11. No abstract available. PMID: 15519011 Free Article
Hlatky MA, Boothroyd DB, Melsop KA, Brooks MM, Mark DB, Pitt B, Reeder GS, Rogers WJ, Ryan TJ, Whitlow PL, Wiens RD.
Circulation. 2004 Oct 5;110(14):1960-6. PMID: 15451795 Free Article
Economic impact of drug-eluting stents on hospital systems: a disease-state model.
Kong DF, Eisenstein EL, Sketch MH Jr, Zidar JP, Ryan TJ, Harrington RA, Newman MF, Smith PK, Mark DB, Califf RM.
Am Heart J. 2004 Mar;147(3):449-56. PMID: 14999193
34th Bethesda Conference: Task force #5–Is atherosclerosis imaging cost effective?
Mark DB, Shaw LJ, Lauer MS, O’Malley PG, Heidenreich P.
J Am Coll Cardiol. 2003 Jun 4;41(11):1906-17. Review. No abstract available. PMID: 12798557
Krumholz HM, Weintraub WS, Bradford WD, Heidenreich PA, Mark DB, Paltiel AD.
J Am Coll Cardiol. 2002 Aug 21;40(4):603-15. Review. No abstract available. PMID: 12204490 Free Article
Medical economics and the assessment of value in cardiovascular medicine: Part II.
Mark DB, Hlatky MA.
Circulation. 2002 Jul 30;106(5):626-30. Review. No abstract available. PMID: 12147547 Free Article
Medical economics and the assessment of value in cardiovascular medicine: Part I.
Mark DB, Hlatky MA.
Circulation. 2002 Jul 23;106(4):516-20. No abstract available. PMID: 12135955 Free Article
Eisenstein EL, Nelson CL, Simon TA, Smitten AL, Lapuerta P, Mark DB.
Am Heart J. 2002 Jun;143(6):1112-7. PMID: 12075271
Obesity and long-term clinical and economic outcomes in coronary artery disease patients.
Eisenstein EL, Shaw LK, Nelson CL, Anstrom KJ, Hakim Z, Mark DB.
Obes Res. 2002 Feb;10(2):83-91. PMID: 11836453 Free Article
Variability in cost of coronary bypass surgery in New York State: potential for cost savings.
Cowper PA, DeLong ER, Peterson ED, Hannan EL, Ray KT, Racz M, Mark DB.
Am Heart J. 2002 Jan;143(1):130-9. PMID: 11773923
Assessing the clinical and economic burden of coronary artery disease: 1986-1998.
Eisenstein EL, Shaw LK, Anstrom KJ, Nelson CL, Hakim Z, Hasselblad V, Mark DB.
Med Care. 2001 Aug;39(8):824-35. PMID: 11468501
Eisenstein EL, Peterson ED, Jollis JG, Tardiff BE, Califf RM, Knight JD, Mark DB.
Pharmacoeconomics. 2000 Mar;17(3):263-72. PMID: 10947301
Barbagelata A, Califf RM, Sgarbossa EB, Goodman SG, Knight D, Mark DB, Granger CB, Agranatti DA, Mautner B, Ohman EM, Suárez LD, Armstrong PW, Gates K, Wagner GS.
Am J Cardiol. 2000 Jul 1;86(1):24-9. PMID: 10867087
Economic end points in phase II trials.
Mark DB, Simons TA.
Am Heart J. 2000 Apr;139(4):S155-7. No abstract available. PMID: 10740122
Cost effectiveness of early discharge after uncomplicated acute myocardial infarction.
Newby LK, Eisenstein EL, Califf RM, Thompson TD, Nelson CL, Peterson ED, Armstrong PW, Van de Werf F, White HD, Topol EJ, Mark DB.
N Engl J Med. 2000 Mar 16;342(11):749-55. PMID: 10717009 Free Article
Mark DB, Harrington RA, Lincoff AM, Califf RM, Nelson CL, Tsiatis AA, Buell H, Mahaffey KW, Davidson-Ray L, Topol EJ.
Circulation. 2000 Feb 1;101(4):366-71. PMID: 10653826 Free Article
Topol EJ, Mark DB, Lincoff AM, Cohen E, Burton J, Kleiman N, Talley D, Sapp S, Booth J, Cabot CF, Anderson KM, Califf RM.
Lancet. 1999 Dec 11;354(9195):2019-24. Erratum in: Lancet 2000 Mar 25;355(9209):1104. PMID: 10636365
Lincoff AM, Mark DB, Tcheng JE, Califf RM, Bala MV, Anderson KM, Davidson-Ray L, Knight JD, Cabot CF, Topol EJ.
Circulation. 2000 Dec 12;102(24):2923-9. PMID: 11113041 Free Article
Pepine CJ, Mark DB, Bourassa MG, Chaitman BR, Davies RF, Knatterud GL, Forman S, Pratt CM, Sopko G, Conti CR.
Am J Cardiol. 1999 Dec 1;84(11):1311-6. PMID: 10614796
Hlatky MA, Boothroyd DB, Brooks MM, Winston C, Rosen A, Rogers WJ, Reeder GS, Smith HC, Ryan TJ, Pitt B, Whitlow PL, Wiens RD, Mark DB.
Am Heart J. 1999 Aug;138(2 Pt 1):376-83. PMID: 10426855
Acute and long-term cost implications of coronary stenting.
Peterson ED, Cowper PA, DeLong ER, Zidar JP, Stack RS, Mark DB.
J Am Coll Cardiol. 1999 May;33(6):1610-8. PMID: 10334432 Free Article
Mark DB, Simons TA.
Am Heart J. 1999 May;137(5):S123-5. No abstract available. PMID: 10220613
Califf RM, Stump D, Topol EJ, Mark DB.
Am Heart J. 1999 May;137(5):S90-3. No abstract available. PMID: 10220606
Mark DB, Simons TA.
Am Heart J. 1999 May;137(5):S38-40. No abstract available. PMID: 10220594
Tung CY, Granger CB, Sloan MA, Topol EJ, Knight JD, Weaver WD, Mahaffey KW, White H, Clapp-Channing N, Simoons ML, Gore JM, Califf RM, Mark DB.
Circulation. 1999 Jan 26;99(3):370-6. PMID: 9918523 Free Article
Value of exercise treadmill testing in women.
Alexander KP, Shaw LJ, Shaw LK, Delong ER, Mark DB, Peterson ED.
J Am Coll Cardiol. 1998 Nov 15;32(6):1657-64. Erratum in: J Am Coll Cardiol 1999 Jan;33(1):289. PMID: 9822093 Free Article
Outcomes and costs within a disease management program for advanced congestive heart failure.
Schulman KA, Mark DB, Califf RM.
Am Heart J. 1998 Jun;135(6 Pt 2 Su):S285-92. Review. No abstract available. PMID: 9630091
Mark DB, Cowper PA, Berkowitz SD, Davidson-Ray L, DeLong ER, Turpie AG, Califf RM, Weatherley B, Cohen M.
Circulation. 1998 May 5;97(17):1702-7. PMID: 9591764 Free Article
Simons GR, Eisenstein EL, Shaw LJ, Mark DB, Pritchett EL.
Am J Cardiol. 1997 Dec 15;80(12):1551-7. PMID: 9416934
Economics of treating heart failure.
Mark DB.
Am J Cardiol. 1997 Oct 30;80(8B):33H-38H. Review. PMID: 9372996
Issues of cost-effectiveness in the use of antithrombotic therapy for ischemic heart disease.
Califf RM, Mark DB.
Am Heart J. 1997 Nov;134(5 Pt 2):S88-96. Review. No abstract available. PMID: 9396640
Geographic variation in resource use for coronary artery bypass surgery. IHD Port Investigators.
Cowper PA, DeLong ER, Peterson ED, Lipscomb J, Muhlbaier LH, Jollis JG, Pryor DB, Mark DB.
Med Care. 1997 Apr;35(4):320-33. PMID: 9107202
Talley JD, Ohman EM, Mark DB, George BS, Leimberger JD, Berdan LG, Davidson-Ray L, Rawert M, Lam LC, Phillips HR, Califf RM.
Am J Cardiol. 1997 Mar 1;79(5):590-4. PMID: 9068514
Hlatky MA, Rogers WJ, Johnstone I, Boothroyd D, Brooks MM, Pitt B, Reeder G, Ryan T, Smith H, Whitlow P, Wiens R, Mark DB.
N Engl J Med. 1997 Jan 9;336(2):92-9. PMID: 8988886 Free Article
Eisenstein EL, Peterson ED, Jollis JG, Tardiff BE, Califf RM, Knight JD, Mark DB.
Proc AMIA Annu Fall Symp. 1997:273-7. PMID: 9357631 Free PMC Article
Eisenstein EL, Mark DB, Califf RM.
Circulation. 1996 Sep 1;94(5):869-71. No abstract available. PMID: 8790017 Free Article
Mark DB, Talley JD, Topol EJ, Bowman L, Lam LC, Anderson KM, Jollis JG, Cleman MW, Lee KL, Aversano T, Untereker WJ, Davidson-Ray L, Califf RM.
Circulation. 1996 Aug 15;94(4):629-35. PMID: 8772681 Free Article
Implications of cost in treatment selection for patients with coronary heart disease.
Mark DB.
Ann Thorac Surg. 1996 Feb;61(2 Suppl):S12-5; discussion S33-4. PMID: 8572825
Economics and Quality of Life After Acute Myocardial Infarction: Insights from GUSTO-I.
Mark DB.
J Thromb Thrombolysis. 1996;3(2):151-155. PMID: 10602556
Barbagelata A, Granger CB, Topol EJ, Worley SJ, Kereiakes DJ, George BS, Ohman EM, Leimberger JD, Mark DB, Califf RM.
Am J Cardiol. 1995 Nov 15;76(14):1007-13. PMID: 7484852
Clinical and economic lessons from studies of coronary thrombolysis.
Mark DB.
J Vasc Interv Radiol. 1995 Nov-Dec;6(6 Pt 2 Suppl):94S-101S. Review. PMID: 8770850
Mark DB, O’Neill WW, Brodie B, Ivanhoe R, Knopf W, Taylor G, O’Keefe JH, Grines CL, Davidson-Ray L, Knight JD, et al.
J Am Coll Cardiol. 1995 Sep;26(3):688-95. PMID: 7642860 Free Article
Mark DB, Hlatky MA, Califf RM, Naylor CD, Lee KL, Armstrong PW, Barbash G, White H, Simoons ML, Nelson CL.
N Engl J Med. 1995 May 25;332(21):1418-24. Erratum in: N Engl J Med 1995 Jul 27;333(4):267. PMID: 7723799 Free Article
Mark DB, Naylor CD, Hlatky MA, Califf RM, Topol EJ, Granger CB, Knight JD, Nelson CL, Lee KL, Clapp-Channing NE, et al.
N Engl J Med. 1994 Oct 27;331(17):1130-5. PMID: 7935638 Free Article
Costs of interventional cardiac procedures.
Mark DB.
J Interv Cardiol. 1994 Aug;7(4):369-78. No abstract available. PMID: 10151067
Jollis JG, Ancukiewicz M, DeLong ER, Pryor DB, Muhlbaier LH, Mark DB.
Ann Intern Med. 1993 Oct 15;119(8):844-50. PMID: 8018127
Dudley RA, Harrell FE Jr, Smith LR, Mark DB, Califf RM, Pryor DB, Glower D, Lipscomb J, Hlatky M.
J Clin Epidemiol. 1993 Mar;46(3):261-71. PMID: 8455051
Hlatky MA, Lipscomb J, Nelson C, Califf RM, Pryor D, Wallace AG, Mark DB.
Circulation. 1990 Nov;82(5 Suppl):IV208-13. PMID: 2225406
Feasibility and cost-saving potential of outpatient cardiac catheterization.
Lee JC, Bengtson JR, Lipscomb J, Bashore TM, Mark DB, Califf RM, Pryor DB, Hlatky MA.
J Am Coll Cardiol. 1990 Feb;15(2):378-84. PMID: 2299080