Statistics and Methodology
Dr. Mark has had the great fortune to work closely with some of the leading biostatisticians and methodologists working in cardiovascular diseases over the last 30 years, and these partnerships have led to some widely cited methodological papers. The 1996 paper with Frank Harrell and Kerry Lee is one of the highest citation papers in the field. The paper with Eisenstein and Anstrom is generally credited with introducing the landmark analysis to cardiovascular outcomes research.
Recent Publications
- Outcomes with revascularisation versus conservative management of participants with 3-vessel coronary artery disease in the ISCHEMIA trial October 21, 2024
- Response to Tomoyuki Kawada: Blood and urine metal levels in patients with diabetes and cardiovascular disease September 6, 2024
- Edetate Disodium-Based Chelation for Patients With a Previous Myocardial Infarction and Diabetes: TACT2 Randomized Clinical Trial August 14, 2024
Statistical and Methodology Publications
Understanding the Role of P Values and Hypothesis Tests in Clinical Research.
Mark DB, Lee KL, Harrell FE Jr.
JAMA Cardiol. 2016 Oct 12. doi: 10.1001/jamacardio.2016.3312. [Epub ahead of print] PMID: 27732700
Au-Yeung WT, Reinhall PG, Poole JE, Anderson J, Johnson G, Fletcher RD, Moore HJ, Mark DB, Lee KL, Bardy GH.
Heart Rhythm. 2015 Oct;12(10):2058-66. doi: 10.1016/j.hrthm.2015.06.030. Erratum in: Heart Rhythm. 2015 Dec;12(12):2520.
PMID: 26096609 Free PMC Article
Nelson CL, Sun JL, Tsiatis AA, Mark DB.
Stat Med. 2008 Nov 20;27(26):5525-55. doi: 10.1002/sim.3355. PMID: 18613251
Clopidogrel use and long-term clinical outcomes after drug-eluting stent implantation.
Eisenstein EL, Anstrom KJ, Kong DF, Shaw LK, Tuttle RH, Mark DB, Kramer JM, Harrington RA, Matchar DB, Kandzari DE, Peterson ED, Schulman KA, Califf RM.
JAMA. 2007 Jan 10;297(2):159-68. PMID: 17148711
Reed SD, Anstrom KJ, Bakhai A, Briggs AH, Califf RM, Cohen DJ, Drummond MF, Glick HA, Gnanasakthy A, Hlatky MA, O’Brien BJ, Torti FM Jr, Tsiatis AA, Willan AR, Mark DB, Schulman KA.
Am Heart J. 2005 Mar;149(3):434-43. PMID: 15864231
Schulman KA, Seils DM, Timbie JW, Sugarman J, Dame LA, Weinfurt KP, Mark DB, Califf RM.
N Engl J Med. 2002 Oct 24;347(17):1335-41. PMID: 12397192 Free Article
Using observational data to estimate prognosis: an example using a coronary artery disease registry.
DeLong ER, Nelson CL, Wong JB, Pryor DB, Peterson ED, Lee KL, Mark DB, Califf RM, Pauker SG.
Stat Med. 2001 Aug 30;20(16):2505-32. PMID: 11512139
Comparing risk-adjustment methods for provider profiling.
DeLong ER, Peterson ED, DeLong DM, Muhlbaier LH, Hackett S, Mark DB.
Stat Med. 1997 Dec 15;16(23):2645-64. Review. PMID: 9421867
Tutorial in Biostatistics: Multivariable prognostic models: issues in developing models, evaluating assumptions and adequacy, and measuring and reducing errors.
Harrell FE Jr, Lee KL, Mark DB.
Stat Med. 1996 Feb 28;15(4):361-87. Review. PMID: 8668867 Free Article
Dudley RA, Harrell FE Jr, Smith LR, Mark DB, Califf RM, Pryor DB, Glower D, Lipscomb J, Hlatky M.
J Clin Epidemiol. 1993 Mar;46(3):261-71. PMID: 8455051
Hlatky MA, Califf RM, Harrell FE Jr, Lee KL, Mark DB, Pryor DB.
J Am Coll Cardiol. 1988 Feb;11(2):237-45. PMID: 3276752 Free Article
Rethinking sensitivity and specificity.
Hlatky MA, Mark DB, Harrell FE Jr, Lee KL, Califf RM, Pryor DB.
Am J Cardiol. 1987 May 1;59(12):1195-8. No abstract available. PMID: 3554956
Clinical data bases. Accomplishments and unrealized potential.
Pryor DB, Califf RM, Harrell FE Jr, Hlatky MA, Lee KL, Mark DB, Rosati RA.
Med Care. 1985 May;23(5):623-47. Review. No abstract available. PMID: 3892181
Tying clinical research to patient care by use of an observational database.
Hlatky MA, Lee KL, Harrell FE Jr, Califf RM, Pryor DB, Mark DB, Rosati RA.
Stat Med. 1984 Oct-Dec;3(4):375-87. No abstract available. PMID: 6396793